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Zyban Warnings and Precautions
To reduce the risk of drug interactions, you should let your healthcare provider know (prior to taking Zyban) about all other medicines you may be taking. A few of the conditions you should tell your healthcare provider about before you take Zyban include diabetes, heart disease, and a brain tumor. Some other Zyban warnings and precautions include the safety of taking Zyban while nursing, the risk of suicidal thinking or behavior in some people who take Zyban, and people who should not take the medicine at all (such as those who are allergic to Zyban or its inactive components).
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You should talk with your healthcare provider prior to taking Zyban® (bupropion SR) if you have:
- Seizures or epilepsy
- A brain tumor
- A history of head trauma or brain injury
- Diabetes
- An eating disorder, such as bulimia or anorexia
- Bipolar disorder(also known as manic depression) or a family history of bipolar disorder
- Heart disease
- A recent history of a heart attack
- A history of suicide attempts or suicidal thoughts
- Liver problems, including liver failure or cirrhosis
- Kidney disease, including kidney failure (renal failure)
- Any allergies, including allergies to food, dyes, or preservatives.
Also let your healthcare provider know if you:
- Are pregnant or thinking of becoming pregnant
- Are breastfeeding
- Drink alcohol regularly.
You should also be sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD



