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Zyban Drug Interactions
When certain medications are taken along with Zyban, drug interactions can occur. These drug interactions with Zyban can cause an increased risk of side effects and may affect the levels of some medications in your system, among other things. Some of the medications that can potentially cause Zyban drug interactions include other antidepressants, beta blockers, MAOIs, and steroids. If drug interactions are a concern, your healthcare provider may adjust your dosages of the medicines and may monitor you more closely.
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Zyban® (bupropion SR) can potentially interact with a number of other medicines. Some of the medicines that can lead to Zyban drug interactions include:
- Alcohol
- Other antidepressants
- Amantadine (Symmetrel®)
- Antipsychotic medications (used to treat hallucinations or schizophrenia)
- Beta blockers, such as:
- Atenolol (Tenormin®)
- Bisoprolol (Zebeta®)
- Carvedilol (Coreg®, Coreg CR®)
- Labetalol (Trandate®)
- Metoprolol (Lopressor®, Toprol XL®)
- Nadolol (Corgard®)
- Propranolol (Inderal®)
- Sotalol (Betapace®)
- Timolol (Blocadren®)
- Certain arrhythmia medications, including propafenone (Rythmol®) and flecainide (Tambocor®)
- Clopidogrel (Plavix®)
- Cyclophosphamide (Cytoxan®)
- Doxorubicin (Adriamycin®, Doxil®)
- Efavirenz (Sustiva®)
- Levodopa (Parcopa®, Sinemet®, Sinemet CR®, Stalevo®)
- Monoamine oxidase inhibitors (MAOIs), including:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Nelfinavir (Viracept®)
- Nicotine patches (NicoDerm CQ®)
- Orphenadrine (Norflex®)
- Ritonavir (Norvir®) or lopinavir and ritonavir (Kaletra®)
- Steroids, such as prednisone or methylprednisolone (Medrol®)
- Tamoxifen (Nolvadex®)
- Theophylline
- Thiotepa
- Ticlopidine (Ticlid®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD