Zyban Drug Interactions

Levodopa
Combining Zyban and levodopa may increase your risk of side effects. To prevent this, your healthcare provider may decide to start you at a lower Zyban dosage if you are taking levodopa.
 
Monoamine Oxidase Inhibitors
You should not take Zyban if you have taken an MAOI within the past 14 days, due to the increased risk of dangerous side effects.
 
Nelfinavir
While it is thought that nelfinavir may interact with Zyban, there have been no reports of such an interaction in actual patients. To be safe, your healthcare provider may choose to monitor you more closely and may need to adjust your doses of these medications if you are taking them together.
 
Nicotine Patches
Taking Zyban while using nicotine patches can cause high blood pressure (hypertension). As a result, your healthcare provider should monitor your blood pressure if you are taking these medications together.
 
Orphenadrine
While it is thought that orphenadrine may interact with Zyban, there have been no reports of such an interaction in actual patients. If you are taking orphenadrine along with Zyban, your healthcare provider may need to monitor you more closely and may choose to adjust your doses of these medications.
 
Ritonavir (Norvir) or Lopinavir and Ritonavir (Kaletra)
Ritonavir (whether taken alone or with lopinavir) may increase the metabolism of Zyban, leading to decreased levels of Zyban in the blood and possibly to decreased effectiveness. Check with your healthcare provider before taking such medications together. You may need a higher Zyban dosage, although the maximum recommended dosage should not be exceeded, even if you are taking ritonavir.
  
Steroids
Taking Zyban with intravenous (IV) or oral steroids can increase your risk of seizures. Talk with your healthcare provider before taking these medications together.
 
Tamoxifen (Nolvadex)
At least theoretically, Zyban could cause tamoxifen to be less effective. Check with your healthcare provider before taking these medications together.
  
Theophylline
Taking Zyban with theophylline can increase your risk of seizures. Talk with your healthcare provider before combining these medications.
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