Zyban Drug Interactions

Beta Blockers
Zyban may raise the levels of beta blockers in your blood, potentially increasing your risk of side effects. Depending on your particular situation, if you are taking these drugs together, your healthcare provider may need to monitor you more closely and may need to decrease your beta blocker dose.
 
Certain Arrhythmia Medications
Zyban can increase the levels of certain arrhythmia medications in your blood, possibly increasing your risk of side effects. To prevent this, your healthcare provider may need to monitor you more closely, especially when you are starting or stopping Zyban.
 
Clopidogrel
Clopidogrel may slow the metabolism of Zyban in the body, potentially leading to high levels of Zyban and a potentially higher risk of Zyban side effects. Check with your healthcare provider before taking these medications together.
  
Cyclophosphamide
While it is thought that cyclophosphamide may interact with Zyban, there have been no reports of such an interaction in actual patients. Depending on your situation, if you are taking cyclophosphamide along with Zyban, your healthcare provider may choose to monitor you more closely and may adjust your doses of these medications.
 
Doxorubicin
Doxorubicin may raise the level of Zyban in your blood, which may increase your chances of side effects. Your healthcare provider may need to decrease your Zyban dose while you are taking doxorubicin.
 
Efavirenz
Efavirenz may increase the metabolism of Zyban, leading to decreased levels of Zyban in the blood, and possibly to decreased effectiveness. Check with your healthcare provider before taking such medications together. You may need a higher Zyban dosage, although the maximum recommended dosage should not be exceeded, even if you are taking efavirenz.
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