Zyban and Weight Loss

In previous clinical studies, weight loss was not a reported side effect of Zyban. This may seem odd, given that the active ingredient of Zyban (buproprion) causes weight loss when used to treat depression. However, because weight gain often occurs when quitting smoking, it is possible that Zyban helps to prevent this weight gain, rather than actually causing weight loss. If you are taking Zyban and weight loss becomes a problem, let your healthcare provider know.

Zyban to Quit Smoking

An Overview of Zyban and Weight Loss

Zyban^® (bupropion SR) is a prescription medicine used for smoking cessation (or to help people quit smoking). There are a number of possible side effects with Zyban. Weight loss, however, does not appear to be one of them. However, bupropion (the active ingredient of Zyban) has been shown to cause weight loss.

Can Zyban Cause Weight Loss?

In studies on Zyban that were conducted before its approval, weight loss was not reported as a side effect. This may seem unusual, because many studies have shown that bupropion causes weight loss when it is used to treat depression (see Wellbutrin SR and Weight Loss). However, quitting smoking often causes weight gain, which is probably why weight loss was not seen as a side effect of Zyban. In fact, very few people taking Zyban reported weight gain (between 1 in 100 and 1 in 1,000 people). So even though Zyban does not appear to help with weight loss per se, it may help prevent or limit weight gain due to stopping smoking.

If you are taking Zyban and weight loss becomes bothersome, talk with your healthcare provider.