Important Information for Your Healthcare ProviderYou should talk with your healthcare provider prior to taking this drug if you have:
- Liver disease, such as liver failure or cirrhosis
- Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Zyflo and Pregnancy)
- Breastfeeding (see Zyflo and Breastfeeding).
Make sure to tell your healthcare provider about all other medicines you may be taking, including prescription and nonprescription medications, vitamins, and herbal supplements.
(Click Precautions and Warnings With Zileuton to learn more, including information on who should not take the drug.)
Zileuton is part of a group of medications called leukotriene synthesis inhibitors. Leukotrienes are chemicals produced by the body in response to allergens or other problems. In the lungs, leukotrienes cause swelling and inflammation in the airways and constriction of the muscles of the respiratory tract.
Zileuton works by stopping the body from producing leukotrienes, preventing these chemicals from causing asthma symptoms.
In studies of zileuton for asthma, people taking the drug had improved breathing and fewer daytime and nighttime asthma symptoms, compared to those not taking the medication. Zileuton was also shown to be safe and effective for treating asthma in children as young as 12 years old.