In February 2008, the manufacturer of Zyflo announced that it has discontinued making this product. The manufacturer stated that since the longer-acting version, Zyflo CR, became available in 2007, use of immediate-release Zyflo declined significantly. Zyflo CR will still be available.
Side Effects of Zileuton: An Introduction
As with any medicine, side effects are possible with
zileuton (Zyflo
®); however, not everyone who takes the medicine will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with zileuton. Your healthcare provider can discuss a more complete list of zileuton side effects with you.)
Common Side Effects of Zileuton
Zileuton has been studied thoroughly in clinical trials, in which a group of people taking the drug have side effects documented. In these studies, the most common zileuton side effects included:
- Headaches -- in up to 24.6 percent of people
- Indigestion or heartburn -- up to 8.2 percent
- Pain -- up to 7.8 percent
- Nausea -- up to 5.5 percent
- Abdominal pain (stomach pain) -- up to 4.6 percent
- Weakness -- up to 3.8 percent
- Accidental injury -- up to 3.4 percent
- Muscle pain -- up to 3.2 percent.
Other common side effects, occurring in 1 to 3 percent of people, included:
