Tracleer Drug Interactions

Tracleer Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Tracleer is combined with any of the drugs listed above.
 
Cyclosporine
Cyclosporine can significantly increase Tracleer blood levels, increasing the risk for serious side effects. In addition, Tracleer can decrease blood levels of cyclosporine. These medications should not be taken together.
 
CYP 2C9 Inducer Medications
The liver breaks down Tracleer using enzymes known as CYP 2C9 enzymes, and medications known as CYP 2C9 inducers can increase the activity of these enzymes. Thus, combining Tracleer with one of these drugs may decrease the level of Tracleer in your body, possibly making it less effective. Talk to your healthcare provider about this potential interaction before taking these medicines together.
 
CYP 2C9 Inhibitor Medications
The liver breaks down Tracleer using enzymes known as CYP 2C9 enzymes, and medications known as CYP 2C9 inhibitors can decrease the activity of these enzymes. Thus, combining Tracleer with one of these drugs may increase the level of Tracleer in your body, potentially increasing your risk for side effects. Talk to your healthcare provider before taking these medicines together. In some cases, this combination will need to be avoided.
 
CYP 3A4 Inducer Medications
The liver breaks down Tracleer using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Tracleer with one of these drugs may decrease the level of Tracleer in your body, possibly making it less effective. Talk to your healthcare provider about this potential interaction before taking these products together.
 
CYP 3A4 Inhibitor Medications
The liver breaks down Tracleer using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Tracleer with one of these drugs may increase the level of Tracleer in your body, potentially increasing your risk for side effects. Talk to your healthcare provider before taking these drugs together. In some cases, this combination will need to be avoided.
 
Glyburide
Tracleer may decrease blood levels of glyburide, which could cause your blood glucose (blood sugar) to increase. Glyburide can decrease blood levels of Tracleer, potentially making it less effective. In addition, combining these drugs has been reported to increase the risk for elevated liver enzymes, which could be a sign of liver damage. These medicines should not be taken together.
 
Hormonal Contraceptives
Tracleer can make hormonal birth control products less effective. This includes any birth control that relies on hormones to work, such as birth control pills, patches, injections, and implants. Because Tracleer can harm an unborn child, it is important to talk to your healthcare provider about the best birth control method to use during treatment.
 
Ketoconazole
Ketoconazole may increase blood levels of Tracleer, possibly increasing the risk for side effects. Talk to your healthcare provider before taking these medications together.
 
Rifampin
Rifampin may increase blood levels of Tracleer within the first few weeks of treatment, but then appears to decrease blood levels. If you take these medicines together, your healthcare provider will need to monitor your liver function using blood tests weekly for the first four weeks because high Tracleer blood levels increase the risk for liver problems. 
 
Ritonavir or Lopinavir and Ritonavir
Ritonavir increases blood levels of Tracleer, which could increase the risk for side effects. People who are taking ritonavir-containing medications should generally be started on lower Tracleer doses. For people who are already taking Tracleer but will be starting a ritonavir medicine, Tracleer should be stopped at least 36 hours before the first dose of ritonavir and then restarted at a lower dose (62.5 mg once daily or every other day) at least 10 days after beginning ritonavir.
 
Certain Statin Medications
Tracleer can decrease blood levels of certain statin medicines, potentially making the medication less effective. If you are taking a statin that could be affected by Tracleer, your healthcare provider should check your cholesterol after starting Tracleer. You may need a higher statin dosage to adequately control your cholesterol. 
 
Tacrolimus
In animal studies, combining tacrolimus and Tracleer increased blood levels of Tracleer. This possible interaction has not been studied in humans. However, to be safe, these medications should be used together with caution.
 
Warfarin
Tracleer may decrease blood levels of warfarin, potentially making the medicine less effective. Talk to your healthcare provider about this possible interaction if you will be taking these drugs together.
 

Tracleer Medication Information

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