Precautions and Warnings With Tobramycin Inhalation Powder

Even though tobramycin inhalation powder may be an effective antibiotic for many people, it can cause serious allergic reactions, side effects, or other complications. In particular, people who have kidney disease or hearing problems should talk to their healthcare provider before using tobramycin inhalation powder. Other safety precautions include warnings for women who are pregnant or nursing, as well as those who are taking certain medications.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using tobramycin inhalation powder (Tobi® Podhaler™) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Hearing problems
  • A balance disorder or dizziness
  • A disorder that affects your muscles, such as myasthenia gravis or Parkinson's disease
  • Had an organ transplant
  • Breathing problems, such as wheezing, coughing, or chest tightness
  • Any allergies, including to foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Tobramycin Inhalation Powder Precautions and Warnings

Some warnings and precautions to be aware of prior to using tobramycin inhalation powder include the following:
  • Like other aminoglycoside antibiotics, this medication has been reported to cause damage to the inner ear, which could lead to hearing loss and balance problems. Let your healthcare provider know if you develop signs of inner ear damage, such as ringing in the ears, changes in hearing, dizziness, or problems with balance. Your healthcare provider may recommend tests during treatment to monitor your hearing.
  • Aminoglycoside antibiotics may cause kidney damage, especially in people who already have kidney problems. Although this did not occur in clinical studies, tobramycin inhalation powder is an aminoglycoside and your healthcare provider may need to monitor how well your kidneys are working during treatment using blood and urine tests.
  • This medicine could worsen muscle weakness and should be used cautiously in people who have conditions that cause muscle weakness, such as myasthenia gravis or Parkinson's disease.
  • Tobramycin inhalation powder can cause bronchospasms (tightening of the airways), which could lead to severe breathing problems. Let your healthcare provider know if you experience wheezing, chest tightness, coughing, or shortness of breath during treatment.
  • In clinical trials, coughing was a common side effect of tobramycin inhalation powder. Let your healthcare provider know if you develop an intolerable or particularly bothersome cough during treatment. He or she may be able to switch you to another medicine.
  • Tobramycin inhalation powder is a pregnancy Category D medication. This means it may harm an unborn child if taken when pregnant (see Tobi Podhaler and Pregnancy).
  • It is unknown whether tobramycin inhalation powder passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Tobi Podhaler and Breastfeeding).

Tobramycin Inhalation Powder Information

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