Tobi Warnings and Precautions

Allergic reactions, kidney damage, and breathing problems are some of the complications that may occur while using Tobi. Other precautions for using this medicine safely include warnings for those who have a hearing problem, balance disorder, or a condition affecting the muscles. There are also warnings for women who are pregnant or breastfeeding.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Tobi® (tobramycin inhalation solution) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Hearing problems
  • A balance disorder or dizziness
  • A disorder that affects your muscles, such as myasthenia gravis or Parkinson's disease
  • Had an organ transplant
  • Breathing problems, such as wheezing, coughing, or chest tightness
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Tobi

Some warnings and precautions to be aware of prior to using this drug include the following:
  • Like other aminoglycoside antibiotics, Tobi may damage the inner ear, which could lead to hearing loss or balance problems. Let your healthcare provider know if you develop signs of inner ear damage, which may include ringing in the ears, hearing loss, dizziness, or problems with balance. Your healthcare provider may recommend hearing tests during Tobi treatment.
  • Aminoglycoside antibiotics, including Tobi, have the potential to damage the kidneys. Although kidney problems did not occur in Tobi clinical studies, your healthcare provider may choose to monitor your kidney function using blood and urine tests during Tobi treatment to be safe. If you show signs of kidney damage, you may need to stop using the medication, at least temporarily.
  • This medicine could worsen muscle weakness and should be used with caution in people who have conditions that affect the muscles, such as myasthenia gravis or Parkinson's disease.
  • Tobi can cause the airways to constrict (tighten), which could lead to severe breathing problems. Let your healthcare provider know if you experience wheezing, chest tightness, cough, or shortness of breath during treatment.
  • Tobi is a pregnancy Category D medication, which means it may harm an unborn child if used during pregnancy (see Tobi and Pregnancy).
  • It is unknown whether Tobi passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Tobi and Breastfeeding).

Tobi Nebulizer Information

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