Sirturo works by blocking an enzyme known as adenosine-5'-triphosphate (ATP) synthase. This enzyme is essential for creating energy that Mycobacterium tuberculosis (the bacteria that causes TB) needs to survive. By blocking this enzyme, Sirturo prevents the bacteria from getting the energy it needs to survive and replicate.
Sirturo is only approved for individuals who are at least 18 years old. It has not been approved for use in children, as it has not been adequately studied in this age group. Talk to your child's healthcare provider about the risks and benefits of using this medication in children.
Sirturo can be used in older adults. However, clinical studies of the drug did not include enough people over the age of 65 to determine whether older adults respond to or tolerate the medication any differently than younger age groups. Until more information is available, Sirturo should probably be used cautiously in older adults.
On occasion, your healthcare provider may recommend this medicine for treating something other than multidrug-resistant TB. This is called an "off-label" use. At this time, there are no well-accepted off-label uses for Sirturo.