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Zyban Interactions ExplainedThe following sections explain in detail the potentially negative interactions that can occur when Zyban is combined with any of the drugs listed above.
It is not recommended that you drink alcohol while taking Zyban. Combining the two may cause unwanted side effects (see Zyban and Alcohol). However, since stopping alcohol abruptly while taking Zyban can increase your risk of seizures, you should talk with your healthcare provider before you stop drinking alcohol.
Taking Zyban with other antidepressants may affect the levels of the medications in your blood, potentially increasing your risk of side effects. Also, taking Zyban with other antidepressants may increase your risk of seizures. Talk with your healthcare provider before combining Zyban with other antidepressant medications.
You should not take Zyban with other products containing bupropion, including Aplenzin™, Budeprion SR®, Buproban®, Budeprion XL®, Forfivo™ XL, Wellbutrin®, Wellbutrin SR®, and Wellbutrin XL®.
Taking Zyban and amantadine together may increase your risk of side effects. To prevent this, your healthcare provider may decide to start you at a lower Zyban dose if you are taking amantadine.
Zyban can raise the levels of some antipsychotic medications in your blood, which may increase your risk of side effects. Also, taking Zyban with antipsychotic medications may increase your chances of seizures. Talk with your healthcare provider before taking these medications together.