Drug Interactions With Linezolid

Tryptophan, antidepressants, blood pressure medications, and several other drugs are known to interact with linezolid. These reactions can lead to serious problems, including a life-threatening reaction called serotonin syndrome. Discussing your current medications with your healthcare provider will minimize the risk of interactions and help ensure a safe treatment process.

An Overview of Linezolid Interactions

Linezolid (Zyvox®) can potentially interact with a number of other medications. Because there are so many linezolid drug interactions that may be quite dangerous, it is important to check with your healthcare provider before taking any medications, whether prescription or over-the-counter (OTC), while you are taking linezolid.
The effects of this medication may continue for two weeks after you stop taking it. Therefore, you may be at risk for drug interactions if you recently took linezolid.
Some of the products that may lead to serious drug interactions with linezolid include but are not limited to:


    • Miscellaneous antidepressants, such as:
    • Monoamine oxidase inhibitors (MAOIs), such as:
  • Pressors, such as:
    • Dopamine (Intropin®)
    • Dobutamine (Dobutrex®)
    • Epinephrine (Adrenalin®, EpiPen®)
    • Norepinephrine (Levophed®)

Linezolid Drug Information

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