Precautions and Warnings With Dornase Alfa

It's important to review precautions and warnings with dornase alfa with your healthcare provider before beginning treatment. This includes telling your healthcare provider if you have certain allergies (such to certain foods or dyes) or if you are pregnant or breastfeeding. Precautions and warnings with dornase alfa also include knowing how to properly take and store the medication.

Dornase Alfa: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking dornase alfa (Pulmozyme®) if you:
  • Have any allergies, including allergies to food, dyes, or preservatives
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
Make sure to tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Dornase Alfa

Warnings and precautions to be aware of prior to taking dornase alfa include the following:
  • Dornase alfa should be used only with other standard treatments for cystic fibrosis.
  • The medication must be stored in the refrigerator. Because it contains no preservatives, the entire ampule must be used (or discarded) as soon as it is opened. This is not usually a problem, since the standard dornase alfa dosage is one full ampule, not a partial one.
  • Dornase alfa is inhaled using a device called a nebulizer. Make sure you know exactly how to use and care for your nebulizer. Do not mix dornase alfa with other nebulizer medications.
  • Dornase alfa is unlikely to interact with other medications (see Drug Interactions With Dornase Alfa).
  • Dornase alfa is considered a pregnancy Category B medication. This means that it is probably safe for using during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using the drug when pregnant (see Pulmozyme and Pregnancy).
  • It is not known if dornase alfa passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider before using dornase alfa (see Pulmozyme and Breastfeeding).

Dornase Alfa -- Cystic Fibrosis Medication

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