Precautions and Warnings With Aztreonam for Inhalation Solution

Potentially serious complications, such as severe allergic reactions and breathing problems, may occur in some people who use aztreonam for inhalation solution. To help ensure a safe treatment, there are a number of safety precautions and warnings for aztreonam for inhalation solution to be aware of, particularly for those who have certain allergies or are taking certain medications.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using aztreonam for inhalation solution (Cayston®) if you have:
  • Breathing problems, such as wheezing, coughing, or chest tightness
  • Any allergies, including to foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Aztreonam for Inhalation Solution Precautions and Warnings

Some warnings and precautions to be aware of prior to using this drug include the following:
  • Some people have had severe allergic reactions to this medication. People who are allergic to antibiotics called beta-lactam antibiotics, such as penicillins, cephalosporins, and carbapenems, may also be allergic to aztreonam for inhalation solution. Let your healthcare provider know if you are allergic to other antibiotics. You should stop using aztreonam for inhalation solution and contact your healthcare provider immediately if you develop signs of an allergic reaction, such as:
    • A facial rash
    • Facial swelling
    • Chest tightness.
  • Aztreonam for inhalation solution can cause the airways to constrict (tighten), which can lead to severe breathing problems, coughing, wheezing, or shortness of breath. To reduce the risk for this potential side effect, your healthcare provider will prescribe an inhaled bronchodilator to take before your aztreonam for inhalation solution dosage. Make sure you understand when and how to use your bronchodilator. Also, let your healthcare provider know if you experience symptoms of airway constriction during treatment.  
  • This medication is only approved to treat people with cystic fibrosis who are known to have a Pseudomonas aeruginosa infection. It should not be used in people with cystic fibrosis who do not have P. aeruginosa in their lungs. The drug will also not work to treat infections caused by viruses, such as the common cold. Using aztreonam for inhalation solution other than how it is prescribed could lead to the development of drug-resistant bacteria.
  • Forced expiratory volume in one second (FEV1) is the amount of air that can be forcibly exhaled from the lungs in the first second of a forced exhalation. It is used to measure lung function. You may experience an improvement in your FEV1 during the 28 days you are using aztreonam for inhalation solution. However, your FEV1 may decline when you stop treatment.
  • This drug is a pregnancy Category B medication, which means it is likely safe for use during pregnancy (see Cayston and Pregnancy).
  • Aztreonam for inhalation solution passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Cayston and Breastfeeding).

Aztreonam for Inhalation Solution Information

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