Precautions and Warnings With Amoxicillin/Clavulanate Potassium XR

Severe diarrhea could indicate a serious reaction to amoxicillin/clavulanate potassium XR, so tell your healthcare provider if you develop this side effect during treatment. Other precautions and warnings with amoxicillin/clavulanate potassium XR include being aware that this antibiotic has no effect on viruses. People who should avoid the drug entirely include those who are allergic to penicillin or who have severe kidney problems.

What Should I Tell My Healthcare Provider?

You should talk to your healthcare provider prior to taking amoxicillin/clavulanate potassium XR (Augmentin XR®) if you have:
  • Liver disease, including liver failure, cirrhosis, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • A penicillin allergy
  • Any other allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all of the medications you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Amoxicillin/Clavulanate Potassium XR Warnings and Precautions

Some warnings and precautions to be aware of prior to taking amoxicillin/clavulanate potassium XR include the following:
  • This product contains amoxicillin, which belongs to the penicillin group of antibiotics. You should not take amoxicillin/clavulanate potassium XR if you are allergic to penicillin. Seek immediate medical attention if you notice any signs of an allergic reaction, such as a rash, itching, hives, wheezing, swelling of the mouth or lips, or difficulty breathing. An allergic reaction to this drug can be dangerous.
  • Let your healthcare provider know if you experience diarrhea that is severe or that lasts for more than two or three days. While diarrhea is a common side effect of amoxicillin/clavulanate potassium XR, severe or prolonged diarrhea may be a sign of a serious reaction to the medication.
  • Your healthcare provider may need to monitor you more closely if you have liver or kidney disease, since these problems often affect the way your body handles medications. Also, amoxicillin/clavulanate potassium XR may make liver or kidney disease worse.
  • Sometimes, antibiotics can cause yeast infections. Let your healthcare provider know if you develop a vaginal yeast infection or thrush (a yeast infection of the mouth) while taking amoxicillin/clavulanate potassium XR.
  • This medicine should not be used to treat viruses, such as the common cold. Amoxicillin/clavulanate potassium XR is completely ineffective for treating viruses, and such use can lead to bacterial resistance to the drug.
  • It is very important to take amoxicillin/clavulanate potassium XR exactly as prescribed. Skipping doses or stopping treatment too early (even if you feel better) can lead to bacterial resistance to the antibiotic.
  • Amoxicillin/clavulanate potassium XR can interact with other medications (see Drug Interactions With Amoxicillin/Clavulanate Potassium XR).
  • This product is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using amoxicillin/clavulanate potassium XR during pregnancy (see Augmentin XR and Pregnancy for more information).
  • Amoxicillin/clavulanate potassium XR passes through breast milk. Therefore, if you are breastfeeding or plan to start, be sure to talk with your healthcare provider (see Augmentin XR and Breastfeeding for more information).
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Amoxicillin/Clavulanate Potassium XR Information

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