Drug Interactions With Amoxicillin/Clavulanate Potassium XR

Allopurinol (Aloprim, Zyloprim)
Combining allopurinol with antibiotics similar to amoxicillin/clavulanate potassium XR increases the risk of skin rashes. It is not known if this is also true with amoxicillin/clavulanate potassium XR.
 
Methotrexate (Rheumatrex, Trexall)
Penicillin-type antibiotics (including amoxicillin/clavulanate potassium XR) may decrease the body's ability to remove methotrexate, leading to high blood levels of methotrexate. Your healthcare provider may need to monitor you more closely in this case.
 
Mycophenolate Mofetil
Amoxicillin/clavulanate potassium XR may decrease the effectiveness of mycophenolate mofetil. Check with your healthcare provider before taking these two medications together.
 
Oral Contraceptives
Despite the long-standing belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics. Ask your healthcare provider about whether or not you need a back-up method of birth control.
 
Oral Typhoid Vaccine
Amoxicillin/clavulanate potassium XR may decrease the effectiveness of the oral typhoid vaccine. If you have taken this drug recently or are currently taking it, your oral typhoid vaccine may need to be postponed for at least a day after stopping the antibiotic.
 
Probenecid (Benuryl)
Probenecid can decrease the body's ability to remove amoxicillin/clavulanate potassium XR from the blood, potentially leading to high levels of amoxicillin/clavulanate potassium XR in the body. Talk with your healthcare provider before taking these medications together.
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Amoxicillin/Clavulanate Potassium XR Information

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