Accolate Warnings and Precautions

Accolate may cause liver damage in some people, leading to symptoms such as fatigue, loss of appetite, dark urine, and yellow eyes or skin (jaundice). Also, the drug is not a fast-acting asthma medication and cannot replace fast-acting rescue inhalers. Understanding these and other warnings and precautions with Accolate will help ensure a safe treatment process.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Accolate® (zafirlukast) if you have:
 
  • Liver disease, such as liver failure or cirrhosis
  • Any allergies, including allergies to food, dyes, or preservatives.
     
Also let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
     
You should also make sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 

Specific Precautions and Warnings With Accolate

Following are some warnings and precautions to be aware of with Accolate:
 
  • Accolate can cause liver damage, rarely resulting in liver failure or death. Let your healthcare provider know right away if you have signs of liver problems, such as:
 
    • Upper right abdominal pain (stomach pain)
    • Nausea
    • Fatigue
    • Flu symptoms (such as a fever or chills)
    • Loss of appetite
    • Yellow eyes or skin
    • Dark urine.
Accolate is not recommended for people who already have liver disease.
  • Accolate is not a fast-acting asthma medication and cannot replace fast-acting rescue inhalers. Do not use Accolate to treat an asthma attack. Everyone taking Accolate for asthma should also have a rescue asthma medication available at all times. Let your healthcare provider know if you need to use your rescue inhaler more frequently than usual, as this may be a sign of worsening asthma.
     
  • Some people who are taking an oral steroid may need to decrease or stop the steroid when starting Accolate. Your healthcare provider should decrease your dose of oral steroid very slowly. Stopping an oral steroid too quickly can be very dangerous.
     
  • Accolate can interact with certain other medications (see Accolate Drug Interactions).
     
  • Accolate is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy -- though the full risks are not known. Talk with your healthcare provider about the risks and benefits of using Accolate during pregnancy (see Accolate and Pregnancy for more information).
     
  • Accolate passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using Accolate (see Accolate and Breastfeeding for more information).
     
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Accolate Drug Information

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