Accolate Drug Interactions
A few of the drugs that can interact with Accolate include cyclosporine, aspirin, and warfarin. Taking these and certain other medicines along with Accolate can alter the levels of medications in your blood, possibly increasing your risk of side effects. You should be sure to tell your pharmacist or healthcare provider about any other medicines you are taking, including nonprescription products.
Accolate® (zafirlukast) can potentially react with some other medicines. Some of the drugs that may lead to Accolate interactions include:
- Carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®, Tegretol XR®)
- Clarithromycin (Biaxin®, Biaxin XL®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Erythromycin (Ery-Tab®)
- Fluconazole (Diflucan®)
- Phenytoin (Dilantil®, Phenytek®)
- Theophylline (Theo-Dur®)
- Tolbutamide (Orinase®)
- Warfarin (Coumadin®, Jantoven®).
The following sections explain in detail the potentially negative interactions that can occur when Accolate is combined with any of the drugs listed above.
Taking Accolate with aspirin may raise the level of Accolate in your blood, possibly increasing your risk of side effects. Talk with your healthcare provider before taking aspirin with Accolate.
Carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR)
Taking carbamazepine with Accolate can raise the level of carbamazepine in your blood, perhaps increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor the level of carbamazepine in your blood -- especially when you are starting or stopping Accolate.