Accolate Drug Interactions

Clarithromycin (Biaxin, Biaxin XL)
Combining Accolate with clarithromycin may decrease the level of Accolate in your blood, perhaps making it less effective. Be sure to let your healthcare provider know if your asthma symptoms worsen while you take clarithromycin.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Taking cyclosporine with Accolate can raise the level of cyclosporine in your blood, perhaps increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor the level of cyclosporine in your blood -- especially when you are starting or stopping Accolate.
 
Erythromycin (Ery-Tab)
Combining Accolate with erythromycin may decrease the level of Accolate in your blood, perhaps making it less effective. Be sure to let your healthcare provider know if your asthma symptoms worsen while you take erythromycin.
 
Fluconazole (Diflucan)
Fluconazole may increase the level of Accolate in the blood. It is unknown how significant this interaction may be. Check with your doctor before taking these medications together.
 
Phenytoin (Dilantin, Phenytek)
Taking phenytoin with Accolate can raise the level of phenytoin in your blood, perhaps increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor the level of phenytoin in your blood -- especially when you are starting or stopping Accolate.
 
Theophylline (Theo-Dur)
Although studies have shown that Accolate does not interact with theophylline, there have been reports of increased theophylline blood levels (and side effects) in people who have combined Accolate with theophylline. If you are taking these drugs together, your healthcare provider may need to monitor the level of theophylline in your blood -- especially when you are starting or stopping Accolate.
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